This zebrafish was imaged using a technique called histomography. Colors indicated a specific assigned intensity and position within the scan. Credit: Provided by the researchers/Penn State
Keith Cheng awarded $3.8M grant from NIH for 3D imaging project
Posted on August 6, 2024Keith Cheng, Penn State Institute for Computational and Data Sciences (ICDS) co-hire and distinguished professor of pathology, of pharmacology and of biochemistry and molecular biology at the Penn State College of Medicine, has been awarded with a four-year, $3.8 million grant from the National Institutes of Health (NIH). This grant is to further develop novel methods for 3D imaging tissue.
Cheng plans to broaden the new form of 3D imaging his research team developed, which is called “X-ray histotomography,” to characterize all tissues and cell types. He will focus on whole traditional models of human biology and disease, such as fruit flies and zebrafish. The research team will also image parts of larger organisms like mice and humans. His technique “uses X-ray beams to take sets of pictures at thousands of angels in two dimensions (2D).” Then, the sets of 2D images are converted into 3D images to create models of plant and animal samples up to a centimeter in diameter.
In a Penn State News article regarding the research, Cheng said, “We are creating models of the entire nervous system in a whole animal from a single 3D image captured in about an hour — a first.”
Cheng is also collaborating with Khai Chung Ang, assistant professor of pathology and scientific director of the zebrafish research facility at Penn State, as well as physicists from the Argonne National Laboratory and the Lawrence Berkeley National Lab.
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